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Related Experiment Video

Updated: May 18, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

Targeting angiogenesis in the pathological ovary.

W Colin Duncan¹, Junko Nio-Kobayashi

¹MRC Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. w.c.duncan@ed.ac.uk

Reproduction, Fertility, and Development

|September 7, 2012

Summary

Investigating ovarian angiogenesis reveals key molecules like vascular endothelial growth factor that regulate blood vessel growth. Targeting these pathways offers therapeutic potential for various ovarian conditions, including cancer and polycystic ovary syndrome.

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In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

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Published on: August 17, 2010

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Last Updated: May 18, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

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Published on: December 5, 2020

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

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Published on: May 16, 2018

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

Area of Science:

Reproductive biology and angiogenesis research.

Background:

The ovary is crucial for studying physiological neovascularization.
Key regulators of ovarian angiogenesis include vascular endothelial growth factor (VEGF), delta-like ligand 4 (DLL4), thrombospondin-1, prokineticin-1, and prostaglandin E2.

Purpose of the Study:

To explore the therapeutic potential of targeting molecular pathways regulating ovarian angiogenesis.
To review the role of angiogenesis manipulation in managing pathological ovarian conditions.

Main Methods:

Literature review on ovarian angiogenesis and its molecular regulators.
Analysis of preclinical and clinical studies involving targeted angiogenesis therapies.

Main Results:

Targeting angiogenic pathways can promote ovarian angiogenesis, enhancing tissue and follicle survival.
Angiogenesis modulation is beneficial in ovarian hyperstimulation syndrome, polycystic ovary syndrome, and ovarian cancer.

Conclusions:

Manipulation of angiogenic pathways holds significant therapeutic promise for diverse ovarian pathologies.
Targeted angiogenesis therapies are increasingly relevant in both preclinical and clinical ovarian disease management.