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Updated: May 18, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[Outcome of an intestinal rehabilitation program for children with short bowel syndrome]
Maarten Schurink1, Vincent B Nieuwenhuijs, Jan B F Hulscher
1Afd. Kinderchirurgie, Universitair Medisch Centrum Groningen, Groningen, the Netherlands. maartenschurink@hotmail.com
Insights
A specialized intestinal rehabilitation program helped 84% of children with short bowel syndrome (SBS) achieve intestinal autonomy. This program significantly improved outcomes for pediatric SBS patients requiring extensive intestinal resection.
Area of Science:
- Pediatric Gastroenterology
- Surgical Outcomes
- Intestinal Rehabilitation
Context:
- Short bowel syndrome (SBS) is a severe condition in children resulting from extensive intestinal resection.
- Intestinal rehabilitation programs aim to improve outcomes for these complex patients.
- Referrals to specialized centers increased, indicating a growing need for such programs.
Purpose:
- To evaluate the effectiveness of a specialized intestinal rehabilitation program for pediatric patients with SBS.
- To assess outcomes including intestinal autonomy, need for transplantation, and survival rates.
Summary:
- A retrospective cohort study analyzed 19 pediatric SBS patients (2001-2009) with a median remaining small intestine of 35 cm.
- After a median of 138 days of total parenteral nutrition, 84% achieved intestinal autonomy.
- Complications included central venous catheter issues (100%), liver dysfunction (68%), and failure to thrive (26%).
Impact:
- The program successfully achieved intestinal autonomy in a high percentage of pediatric SBS patients.
- It reduced the need for intestinal transplantation, with only one liver transplant performed.
- The findings highlight the critical role of specialized intestinal rehabilitation in managing pediatric SBS.
Objective:
To evaluate an intestinal rehabilitation program, introduced in 2001, for children who developed short bowel syndrome (SBS) after extensive intestinal resection.
Design:
Retrospective cohort study.
Method:
General information on disease status and outcome of intestinal rehabilitation plus demographic data on all SBS patients, treated in the programme between 2001 and 2009, were collected. The outcome measures were intestinal autonomy, intestinal and/or liver transplantation and survival.
Results:
A total of 10 boys and 9 girls, born at a median gestational age of 36 weeks, were treated according to intestinal rehabilitation programme guidelines. Eight of them had been referred to our centre from elsewhere, 3 times as many as in 1991-2000. The causes of SBS were: intestinal atresia (n = 3), gastroschisis (n = 2), volvulus (n = 9), necrotising enterocolitis (n = 3) or strangulation (n = 2). Median remaining small-intestinal length was 35 cm (range: 10-70 cm). In 14 patients the ileocecal valve was still present and in all 19 patients at least 25% of the colon remained. The median follow-up period was 25 months (range: 50 days-9 years). Following total parenteral nutrition lasting a median 138 days (range: 41 days-11 years), 16 patients (84%) reached intestinal autonomy. Central venous catheter-related complications occurred in all of the patients; liver function disorders in 13 (68%) and failure to thrive in 5 (26%). One patient underwent an intestinal lengthening procedure. None of the patients needed an intestinal transplantation, but one patient underwent a liver transplantation for intestinal failure associated liver disease. Overall mortality was 11%: 2 patients died of abdominal sepsis.
Conclusion:
The specialised intestinal rehabilitation programme led to intestinal autonomy in 84% of the patients with SBS.
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