Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

Blind Procedures

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring work motivation in High and Intensive Care wards with the confession booth: An innovative approach.

International journal of nursing studies advances·2026

Same author

Next generation sequencing approaches for the detection and characterization of enteroviruses in clinical, public health, and research settings: Expert view of the European non-polio enterovirus network (ENPEN).

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2026

Same author

Interrelationships of long-term changes in recovery domains among patients with schizophrenia spectrum disorders: a six-year follow-up study.

BMC psychiatry·2025

Same author

Development of a machine learning model for predicting compulsory psychiatric care using clinical notes.

BMC psychiatry·2025

Same author

Monitoring arts and psychomotor therapies: Further development and validation of the Self-expression and Emotion-Regulation in Arts and Psychomotor Therapies Scale (SERAPTS).

PloS one·2025

Same author

Attachment and Social Functioning in Patients with a Psychosis Spectrum Disorder: A Mediation Study.

Schizophrenia bulletin open·2025

Search research articles

Related Experiment Video

Updated: May 18, 2026

Reducing State Anxiety Using Working Memory Maintenance

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Reducing seclusion through involuntary medication: a randomized clinical trial.

Irina Georgieva¹, Cornelis L Mulder, Eric Noorthoorn

¹Research Center O3, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands; Mental Health Center Western North-Brabant, Halsteren, The Netherlands.

Psychiatry Research

|September 7, 2012

Summary

Involuntary medication reduced seclusion incidents in psychiatric care but did not decrease overall coercive events. Further interventions are needed to manage acute aggression effectively.

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Related Experiment Videos

Last Updated: May 18, 2026

Reducing State Anxiety Using Working Memory Maintenance

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Area of Science:

Psychiatry
Clinical Psychology
Health Services Research

Background:

Managing agitation and violence in acute psychiatric wards often involves restrictive interventions.
Seclusion and involuntary medication are common, yet controversial, methods for patient safety.

Purpose of the Study:

To determine if prioritizing involuntary medication over seclusion reduces the frequency and duration of coercive incidents.
To compare the effectiveness of two intervention strategies for acute aggression management.

Main Methods:

Randomized controlled trial comparing involuntary medication (Group 1) versus seclusion (Group 2) as first-choice interventions.
Statistical analysis of seclusion and involuntary medication incidence rates and durations using Pearson chi-squared and t-tests.
Calculation of risk ratios (RRs) to assess differences in coercive incidents.

Main Results:

Group 1 showed a lower relative risk of seclusion but a higher risk of involuntary medication compared to Group 2.
No significant differences were found in the mean duration of seclusion or the total number of coercive incidents between the groups.
Involuntary medication effectively substituted for seclusion, reducing its incidence.

Conclusions:

While involuntary medication can decrease seclusion rates, it does not reduce the overall number or duration of coercive incidents.
Alternative strategies are required to comprehensively manage acute aggression and reduce overall patient restraint.
Implementing new policies for acute aggression, like involuntary medication, necessitates specific supportive conditions for effectiveness.