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Related Experiment Videos

Residual strain in rat left ventricle.

J H Omens1, Y C Fung

  • 1Department of Applied Mechanics and Engineering Sciences (Bioengineering), University of California San Diego, La Jolla 92093.

Circulation Research
|January 1, 1990
PubMed
Summary

Researchers measured residual strains in rat hearts to understand their impact on left ventricular wall stress. Findings reveal asymmetric strain distributions, suggesting a single radial cut can approximate a stress-free state.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Physiology
  • Computational Mechanics

Background:

  • Residual stress, the internal stress in an organ without external loads, is often overlooked in left ventricular (LV) wall stress analyses.
  • Accurate LV stress distribution analysis requires incorporating residual stress, necessitating measurement of residual strain in the heart's no-load state.

Purpose of the Study:

  • To measure residual strains in rat left ventricles to better understand their contribution to cardiac mechanics.
  • To establish a method for quantifying residual strains in cardiac tissue.

Main Methods:

  • Equatorial cross-sectional rings from arrested rat left ventricles were analyzed.
  • Specimens were submerged in fluid to minimize friction and external loading.

Related Experiment Videos

  • Microspheres tracked deformations after radial cuts to compute 2D strains, defining residual strains.

    • Main Results:

    • Principal residual stretch ratio distributions were asymmetric relative to the radial cut.
    • Substantial transmural strain gradients showed differing strain component distributions on either side of the cut.
    • A second radial cut induced significantly smaller deformations than the first.

    Conclusions:

    • A single radial cut on a cardiac tissue slice can approximate a stress-free state.
    • Residual strain measurements are crucial for accurate left ventricular wall stress modeling.
    • Asymmetric strain distributions highlight the complexity of cardiac residual stress.