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Related Experiment Video

Updated: May 18, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

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[Injectable extended-release naltrexone for opioid dependence: a double-blind, placebo-controlled, multicentre

E M Krupitskiĭ, E V Nunes, W Ling

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova

|September 7, 2012

Summary

Extended-release naltrexone (XR-NTX) injections effectively treat opioid dependence post-detoxification. Combined with counseling, XR-NTX significantly improves abstinence rates compared to placebo.

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Published on: August 4, 2022

Area of Science:

Pharmacology
Addiction Medicine
Clinical Trials

Context:

Opioid dependence remains a significant public health issue requiring effective long-term treatment strategies.
Post-detoxification management is crucial to prevent relapse and support sustained recovery.
Novel therapeutic formulations are needed to improve patient adherence and treatment outcomes.

Purpose:

To evaluate the efficacy and safety of an extended-release injectable formulation of naltrexone (XR-NTX) for patients with opioid dependence following detoxification.
To compare the effectiveness of XR-NTX combined with psychosocial treatment against placebo with psychosocial support over a 24-week period.

Summary:

A 24-week, double-blind, placebo-controlled trial randomized 250 patients with opioid dependence to receive either 380 mg of XR-NTX or placebo, alongside biweekly counseling sessions.
The primary endpoint, confirmed abstinence from week 5 to 24, was assessed via urine drug tests and self-reporting.
Secondary endpoints included opioid-free days, craving scores, treatment retention, and relapse rates.

Impact:

XR-NTX, when administered monthly with psychosocial support, offers a promising new pharmacological option for managing opioid dependence.
This injectable formulation demonstrated superior efficacy in maintaining abstinence and reducing relapse compared to placebo, highlighting its potential clinical utility.