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Updated: May 18, 2026
05:51
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
In vivo fluorescence imaging with Ag2S quantum dots in the second near-infrared region
Guosong Hong1, Joshua T Robinson, Yejun Zhang
1Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Angewandte Chemie (International Ed. in English)
|September 7, 2012
Abstract:
Hits the dot: Ag(2)S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating were synthesized for in vivo small-animal imaging. The 6PEG-Ag(2)S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag(2)S QDs occurs mainly through the biliary pathway in mice.
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