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Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

Production of Formed Elements

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

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Related Experiment Video

Updated: May 18, 2026

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

Hematopoietic stem cell mobilization: updated conceptual renditions.

H Bonig¹, T Papayannopoulou

¹Department of Medicine/Division of Hematology, University of Washington, Seattle, WA 98198-7720, USA.

|September 7, 2012

Summary

Hematopoietic stem cell mobilization research seeks to understand how stem cells are retained in the bone marrow niche. Recent advances aim to reconcile mobilization data and identify common mechanisms across different strategies.

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In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

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Area of Science:

Hematology
Stem Cell Biology
Cellular Trafficking

Background:

Hematopoietic stem cell (HSC) mobilization is crucial for stem cell transplantation and understanding stem cell retention in the bone marrow niche.
Pharmacologic HSC mobilization research offers insights into stem cell-niche interactions, stem cell engineering, and targeting malignant stem cells.
Despite clinical relevance, HSC mobilization mechanisms remain complex and incompletely understood.

Purpose of the Study:

To review recent advances in hematopoietic stem cell mobilization.
To reconcile inconsistent findings in stem cell mobilization research.
To identify commonalities among various stem cell mobilization strategies.

Main Methods:

Review of recent scientific literature on hematopoietic stem cell mobilization.
Analysis of data from various mobilization regimes, including CXCR4 antagonists.
Synthesis of information to explain complex stem cell mobilization mechanisms.

Main Results:

Recent advances in understanding HSC mobilization mechanisms have been reported.
Efforts are underway to reconcile seemingly contradictory data in the field.
Commonalities among different mobilization approaches are being identified.

Conclusions:

Understanding stem cell mobilization is key to improving stem cell transplantation and cancer therapy.
Further research is needed to fully elucidate the complex mechanisms of HSC mobilization.
Reconciling existing data and identifying commonalities will advance the field of stem cell mobilization.