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Related Concept Videos

Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

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Updated: May 18, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Tremor in inflammatory neuropathies.

Tabish Aziz Saifee1, Petra Schwingenschuh, Mary M Reilly

  • 1Sobell Department, UCL Institute of Neurology, London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|September 7, 2012
PubMed
Summary
This summary is machine-generated.

Tremor is common in inflammatory neuropathies, contributing to disability but often not responding to treatment. Tremor severity correlates with F wave latency in these patients.

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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

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Last Updated: May 18, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Tremor is a known symptom in neuropathies, with variable prevalence and poorly understood causes.
  • Disability from tremor in Charcot-Marie-Tooth disease is documented, but not in inflammatory neuropathies.
  • Limited data exists on neuropathic tremor treatment response and its selective occurrence.

Purpose of the Study:

  • To investigate the prevalence and severity of tremor in patients with inflammatory neuropathies.
  • To explore the relationship between tremor and disability in this patient group.
  • To assess the response of neuropathic tremor to treatment.

Main Methods:

  • Case control study of 43 patients with inflammatory neuropathies.
  • Clinical assessments included Fahn-Tolosa-Marin Scale, sensory/power scores, and Overall Neuropathy Limitations Scale.
  • Nerve conduction studies and accelerometry for tremor recording were utilized.

Main Results:

  • Tremor was prevalent in IgM paraproteinaemic neuropathies, chronic inflammatory demyelinating polyradiculoneuropathy (58%), and multifocal motor neuropathy with conduction block (56%).
  • Tremor generally proved refractory to treatment, with minor improvements seen in some cases after underlying neuropathy treatment.
  • Tremor severity correlated with F wave latency but did not distinguish between patients with or without tremor.

Conclusions:

  • Tremor is a frequent and disabling symptom in inflammatory neuropathies.
  • Treatment of the underlying neuropathy offers limited improvement for tremor.
  • F wave latency is associated with tremor severity in these conditions.