Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The neural basis of creative thought: An activation likelihood estimation meta-analysis of 787 experiments.

Cortex; a journal devoted to the study of the nervous system and behavior·2026

Same author

The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.

Brain communications·2026

Same author

All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex.

Imaging neuroscience (Cambridge, Mass.)·2026

Same author

Self-blame-selective social conceptual overgeneralisation and vulnerability to depression.

Cortex; a journal devoted to the study of the nervous system and behavior·2026

Same author

Transcranial focused ultrasound stimulation enhances semantic memory by modulating brain morphology, neurochemistry and neural dynamics.

Nature communications·2026

Same author

A common framework for semantic memory and semantic composition.

Imaging neuroscience (Cambridge, Mass.)·2026

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 18, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Connectivity-based structural and functional parcellation of the human cortex using diffusion imaging and

Lauren L Cloutman¹, Matthew A Lambon Ralph

¹Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester Manchester, UK.

Frontiers in Neuroanatomy

|September 7, 2012

Summary

Brain parcellation using diffusion imaging and white matter tractography offers a novel, non-invasive approach to map cortical regions. This method shows promise in identifying distinct subregions that align with functional and traditional parcellation schemes.

Keywords:

connectivity cytoarchitecture diffusion functional specialization tractography

More Related Videos

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Related Experiment Videos

Last Updated: May 18, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

Neuroscience
Neuroimaging
Computational Anatomy

Background:

Cortical parcellation, the division of the cerebral cortex into distinct regions, has been a long-standing challenge in neuroscience.
Existing parcellation schemes based on anatomical or cytoarchitectonic properties lack universal acceptance.
Understanding the structural and functional organization of the human brain is crucial for neuroscience research.

Purpose of the Study:

To review the application of in vivo diffusion imaging and white matter tractography for human cortical parcellation.
To discuss the strengths and limitations of using white matter connectivity for defining cortical regions.
To explore the correlation between connectivity-based parcellation and established functional and cytoarchitectonic methods.

Main Methods:

Utilizing diffusion imaging to visualize white matter pathways in vivo.
Employing white matter tractography to reconstruct structural brain networks.
Analyzing connectivity profiles to segregate functionally distinct cortical regions.

Main Results:

Evidence suggests that white matter connectivity-based parcellation can identify distinct cortical subregions.
These connectivity-derived regions show strong correlations with functional areas identified by fMRI and meta-analyses.
A notable parallel exists between tractography-defined regions and traditional cytoarchitectonic parcellation methods.

Conclusions:

Diffusion tractography provides a non-invasive means to map structural brain networks and offers a promising approach for cortical parcellation.
While connectivity-based parcellation aligns with functional and cytoarchitectonic methods, further research is needed to clarify their precise correspondence and functional significance.
Continued refinement of diffusion tractography is vital for advancing our understanding of brain organization in health and neurological disease.