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Related Experiment Video

Updated: May 18, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Structural Changes in the Insular Cortex in Alcohol Dependence: A cross sectional study.

Somsubhra Chattopadhyay¹, Mona Srivastava, Adya Shanker Srivastava

¹Department of Psychiatry, Medical College, Kolkata, India.

Iranian Journal of Psychiatry

|September 7, 2012

Summary

Alcohol dependence causes brain atrophy, particularly in the insular cortex, independent of age. Cognitive functions are significantly impaired in individuals with alcohol dependence syndrome.

Keywords:

Alcohol related disorders Cerebral cortex Cognition Computed tomography

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Area of Science:

Neuroscience
Psychiatry
Radiology

Background:

Alcohol dependence syndrome (ADS) is a prevalent condition with significant neurological consequences.
The insular cortex plays a crucial role in various cognitive and emotional functions.
Understanding structural brain changes in ADS is vital for clinical management.

Purpose of the Study:

To investigate changes in the insular cortex of individuals with alcohol dependence.
To compare these changes with a control group.
To correlate structural findings with clinical and cognitive assessments.

Main Methods:

A case-control study involving 30 subjects with ADS and 30 matched controls.
Computerized tomography (CT) scans were used to assess brain structure.
The Mini-Mental Status Examination (MMSE) was administered to evaluate cognitive function.

Main Results:

Subjects with ADS exhibited higher rates of cortical atrophy compared to controls, though not statistically significant.
Cognitive functioning, as measured by MMSE scores, was significantly impaired in the ADS group.
Analysis indicated significant frontal and parietal cortical atrophy in the ADS group.

Conclusions:

Alcohol dependence is associated with age-independent cerebral atrophy.
The findings suggest involvement of the insular cortex in alcohol dependence.
Impaired cognitive function and structural changes highlight the neurotoxic effects of alcohol.