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Sucralfate enema in ulcerative rectosigmoid lesions
R Kochhar1, S K Mehta, R Aggarwal
1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Diseases of the Colon and Rectum
|January 1, 1990
Summary
Sucralfate enemas effectively treated ulcerative lesions in the rectosigmoid for 86% of patients. This safe and useful treatment showed significant clinical and sigmoidoscopic improvements in radiation proctitis and other conditions.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Medical Therapeutics
Background:
- Ulcerative lesions in the distal colon, including radiation proctitis, idiopathic ulcerative proctitis, and solitary rectal ulcer, often present treatment challenges.
- Conventional therapies may be insufficient for some patients with these conditions or those with ulcerated rectal polyps.
Purpose of the Study:
- To evaluate the efficacy of sucralfate enemas in managing various ulcerative lesions of the rectosigmoid.
- To determine the safety and effectiveness of sucralfate suspension administered via enema.
Main Methods:
- A study involving 22 patients with refractory ulcerative rectosigmoid lesions.
- Patients received sucralfate suspension enemas (2 gm in 20 ml water) twice daily for three weeks.
Main Results:
- Significant clinical improvement was observed in 19 out of 22 patients (86%).
- Sigmoidoscopic improvements were noted in 18 out of 22 patients (82%).
- No adverse side effects were reported during the treatment period.
Conclusions:
- Sucralfate enemas demonstrate significant efficacy in treating ulcerative lesions of the rectosigmoid.
- The treatment is well-tolerated and shows promise for conditions like radiation proctitis and solitary rectal ulcer.