Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Prosopagnosia01:24

Prosopagnosia

Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Disseminated Nocardiosis due to <i>Nocardia otitidiscaviarum</i> With Pulmonary Infection and a Thyroid Abscess.

Respirology case reports·2026
Same author

Diagnostic performance of kinetic parameters of ultrafast breast MRI and their associations with immunohistopathological findings of breast carcinoma.

Scientific reports·2026
Same author

Advances in Visualizing Cytosine Methylation and Allele-Specific Epigenetic States in Tissue Context.

Pathology international·2026
Same author

Visceral technetium-99 m-labeled pyrophosphate uptake in patients with wild-type transthyretin cardiac amyloidosis.

Annals of nuclear medicine·2026
Same author

Quantitative spectroscopic analysis of talaporfin sodium fluorescence: Utility in fluorescence-guided surgery and detection of invasive tumor cells in glioblastoma.

Surgical neurology international·2026
Same author

Spatial transcriptomics of urothelial carcinoma with basal/squamous differentiation identifies Galectin-7 as a specific marker of squamous lineage commitment.

Discover oncology·2026

Related Experiment Video

Updated: May 18, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Multiple-system atrophy in long-term professional painter: a case report.

Yusa Nagai1, Riko Kitazawa, Miku Nakagawa

  • 1Division of Molecular Pathology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime, Toon City, 791-0295, Japan.

Case Reports in Pathology
|September 7, 2012
PubMed
Summary

This autopsy case highlights a rare neurodegenerative disorder, Multiple System Atrophy (MSA), diagnosed in a professional painter. Diagnosis was confirmed by alpha-synuclein staining, suggesting environmental factors may contribute to MSA development.

More Related Videos

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Applying Hyperspectral Reflectance Imaging to Investigate the Palettes and the Techniques of Painters
07:05

Applying Hyperspectral Reflectance Imaging to Investigate the Palettes and the Techniques of Painters

Published on: June 18, 2021

Related Experiment Videos

Last Updated: May 18, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Applying Hyperspectral Reflectance Imaging to Investigate the Palettes and the Techniques of Painters
07:05

Applying Hyperspectral Reflectance Imaging to Investigate the Palettes and the Techniques of Painters

Published on: June 18, 2021

Area of Science:

  • Neurodegenerative Disorders
  • Neuropathology
  • Toxicology

Background:

  • Multiple system atrophy (MSA) is a rare, severe, progressive neurodegenerative disorder.
  • This report details an autopsy case of MSA in a long-term professional painter.

Purpose of the Study:

  • To describe an unusual case of MSA in a professional painter.
  • To explore potential contributing factors to MSA pathogenesis.

Main Methods:

  • Autopsy and histopathological examination.
  • Immunohistochemical staining for alpha-synuclein.
  • Review of patient's occupational and medical history.

Main Results:

  • Diagnosis of MSA (OPCA+SDS) confirmed by alpha-synuclein-positive glial cytoplasmic inclusions (GCI) in oligodendroglia.
  • Significant neuronal loss and gliosis observed in multiple brain and spinal cord regions.
  • Absence of typical GCI in routine histology, emphasizing the importance of specific staining.

Conclusions:

  • Prolonged exposure to organic solvents in professional painters may be a risk factor for MSA.
  • Hyperglycemic morbidity from diabetes might influence MSA onset and progression.
  • Further research is needed to elucidate the role of environmental factors and comorbidities in MSA pathogenesis.