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Updated: May 18, 2026

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

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Optic nerve hemangioblastoma: a case report.

Holly Zywicke¹, Cheryl Ann Palmer, Michael S Vaphiades

¹Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Case Reports in Pathology

|September 7, 2012

Summary

Optic nerve hemangioblastomas are rare central nervous system tumors. Early diagnosis is crucial, as these tumors can impact vision and potentially follow a more aggressive course.

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Area of Science:

Neuro-oncology
Ophthalmology
Neuropathology

Background:

Hemangioblastomas are WHO grade I tumors of uncertain origin, typically affecting the central nervous system.
They commonly occur in the posterior fossa, brainstem, and spinal cord.
Optic nerve hemangioblastomas are exceptionally rare, with fewer than 20 cases reported.

Observation:

A patient presented with visual decline due to a mass in the posterior orbital canal.
The mass was observed to grossly involve the optic nerve sheath.
Neuropathologic evaluation confirmed the diagnosis of hemangioblastoma.

Findings:

This case represents a rare instance of hemangioblastoma originating within the posterior orbital canal and involving the optic nerve sheath.
The tumor's location and involvement of the optic nerve underscore its potential impact on visual function.

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Last Updated: May 18, 2026

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Published on: October 15, 2017

Implications:

Hemangioblastoma should be considered in the differential diagnosis for orbital masses causing visual decline.
Prompt recognition and management are vital due to the potential for aggressive behavior and significant visual prognosis impact.