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Updated: May 18, 2026

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
[Dupuytren’s disease – the story of an eponym]
163, boulevard des Invalides, 75007 Paris, France. glicenstein@free.fr
Abstract:
December 5, 1831, baron Guillaume Dupuytren presents at the surgical clinics of the Hotel-Dieu of Paris a report upon "an entirely new subject, with a new theory and a new method of treatment for a disease generally regarded as incurable". The patient presented had a permanent contraction of the ring finger and adjacent fingers of both hands, which appeared spontaneously without any injury or previous illness. Dupuytren explains he had the opportunity to dissect the hand of a man who died after having had a contraction of the fingers for many years. He defines the cause of the contraction to be the palmar fascia. He describes the operative treatment: aponeurotomy by a transverse incision. "Probably many surgeons (Cline 1808, Astley Cooper 1822) were aware of the palmar aponeurosis producing this condition before Dupuytren's lecture". "Thoroughness of his demonstration, the brilliance of the presentation and the supremacy of his surgical authority combined to link permanently the name of Dupuytren with this hand deformity" (J. Hueston).
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