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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Updated: May 18, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Basic geriatric assessment does not predict in-hospital mortality after PEG placement.

Christine Smoliner¹, Dorothee Volkert, Anke Wittrich

¹Department of Internal Medicine and Geriatrics, St,-Marien-Hospital Borken, Am Boltenhof 7, 46325, Borken, Germany.

|September 8, 2012

Summary

This summary is machine-generated.

Percutaneous endoscopic gastrostomy (PEG) in geriatric patients shows higher mortality risk with advanced age, male sex, and pneumonia. Standard geriatric assessments did not predict in-hospital death, highlighting the need for individualized care decisions.

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Area of Science:

Geriatric Medicine
Gastroenterology
Clinical Outcomes Research

Background:

Percutaneous endoscopic gastrostomy (PEG) is crucial for long-term nutrition in geriatric patients.
Patient selection is critical due to potentially high mortality rates in this demographic.
Identifying risk factors for in-hospital mortality post-PEG is essential for improving patient care.

Purpose of the Study:

To analyze data on geriatric patients undergoing PEG placement.
To identify specific risk factors associated with in-hospital mortality in this population.

Main Methods:

Retrospective analysis of the GEMIDAS database (2006-2010) for patients in acute geriatric wards.
Inclusion of data on demographics, diagnoses, care levels, cognitive status (MMSE), and self-care capacity (Barthel index).
Logistic regression analysis to determine factors influencing in-hospital mortality.

Main Results:

1232 geriatric patients (median age 82) included; 12.8% in-hospital mortality.
Risk factors for mortality included advanced age, male sex, pneumonia, and 'miscellaneous disease' diagnoses.
Cognitive status and Barthel index at admission did not significantly influence mortality.

Conclusions:

Standard geriatric assessment components were not significant predictors of mortality post-PEG.
Individualized decision-making is emphasized for PEG placement in geriatric patients.
The study underscores the complexity of predicting outcomes in elderly patients requiring nutritional support.