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Updated: May 4, 2026

Processing of Human Reduction Mammoplasty and Mastectomy Tissues for Cell Culture
Published on: January 3, 2013
Site-specific pathology in breast reduction mammoplasty
Xiao Long1, Xiao-jun Wang, Yang Wang
1Department of Plastic and Reconstructive Surgery, PUMC Hospital, CAMS and PUMC, Beijing, China.
Site-specific pathology during breast reduction mammoplasty is feasible and valuable. The clock-wise method aids in tumor localization, enabling skin-spared surgery for breast cancer patients.
Area of Science:
- Oncology
- Plastic Surgery
- Pathology
Background:
- Breast reduction mammoplasty is a common procedure.
- Accurate pathological assessment of excised tissue is crucial for patient management.
- Identifying malignancy during reduction mammoplasty can alter surgical plans.
Purpose of the Study:
- To evaluate the feasibility and clinical significance of site-specific pathological examination in breast reduction mammoplasty.
- To assess the utility of the clock-wise method for specimen orientation.
Main Methods:
- A retrospective review of 127 patients undergoing breast reduction mammoplasty between June 2007 and June 2010.
- Pathological specimens were analyzed using the clock-wise method for precise localization.
- Patients diagnosed with cancer underwent breast-conserving surgery.
Main Results:
- Glandular hyperplasia was observed in 53 patients (41.7%), and fibroadenoma in 7 patients (5.5%).
- One patient (0.79%) was diagnosed with ductal carcinoma in situ, successfully treated with breast-conserving surgery, chemotherapy, and radiotherapy.
- No relapse was reported in the cancer patient during a three-year follow-up period.
Conclusions:
- The clock-wise method is effective for tumor localization in breast reduction mammoplasty specimens.
- This technique facilitates skin-spared breast resection, even when malignancy is detected.
- Site-specific pathology enhances the safety and efficacy of breast reduction procedures.
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