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Updated: May 18, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Volume-limited and volume-targeted ventilation
1Neonatal Research, The Royal Women's Hospital, Melbourne, Australia, 23 High Street, Great Shelford, Cambridge CB22 5EH, United Kingdom. colin@morleys.net
Abstract:
This article shows that volume-targeted ventilation is physiologically more logical than pressure-limited ventilation, and is associated with a reduced risk of pneumothorax, hypocarbia, duration of ventilation, death or bronchopulmonary dysplasia, and severe intraventricular hemorrhage. Therefore, it should now be adopted as the main mode for mechanical ventilation of preterm neonates.
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