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Mechanical Ventilation II: Invasive Ventilation

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...

Ventilatory Modes

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Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

Mechanical Ventilation I: Indication and Settings

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...

Respiratory Volumes and Capacities

Respiratory Volumes and Capacities

The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...

Respiratory Volumes

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...

Mechanical Ventilation III: Noninvasive Ventilation

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)

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Related Experiment Video

Updated: May 18, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Volume-limited and volume-targeted ventilation.

Colin J Morley¹

¹Neonatal Research, The Royal Women's Hospital, Melbourne, Australia, 23 High Street, Great Shelford, Cambridge CB22 5EH, United Kingdom. colin@morleys.net

Clinics in Perinatology

|September 8, 2012

Summary

This summary is machine-generated.

Volume-targeted ventilation is a safer mechanical ventilation method for preterm neonates. This approach reduces risks of pneumothorax, hypocarbia, and bronchopulmonary dysplasia, improving outcomes.

Related Experiment Videos

Last Updated: May 18, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Area of Science:

Neonatal medicine
Pediatric respiratory care
Mechanical ventilation strategies

Background:

Mechanical ventilation is critical for preterm neonates but carries risks.
Traditional pressure-limited ventilation (PLV) may lead to lung injury.
Optimizing ventilation modes is essential for improving survival and reducing morbidity.

Purpose of the Study:

To compare the physiological logic and clinical outcomes of volume-targeted ventilation (VTV) versus pressure-limited ventilation (PLV).
To evaluate the association of VTV with reduced risks of specific adverse events in preterm neonates.

Main Methods:

The study compares VTV and PLV in preterm neonates.
Physiological rationale and clinical outcomes including pneumothorax, hypocarbia, ventilation duration, mortality, bronchopulmonary dysplasia, and intraventricular hemorrhage are assessed.

Main Results:

Volume-targeted ventilation is physiologically more logical than pressure-limited ventilation.
VTV is associated with reduced risks of pneumothorax, hypocarbia, prolonged ventilation, death, bronchopulmonary dysplasia, and severe intraventricular hemorrhage.

Conclusions:

Volume-targeted ventilation should be the primary mode for mechanical ventilation in preterm neonates.
Adoption of VTV can significantly improve clinical outcomes and reduce complications.