Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Assessment of Airway, Skin Color, and Use of Accessory Muscles

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Stereotypes, Prejudice, and Discrimination

Stereotypes, Prejudice, and Discrimination

Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A comparison of telehealth and in-person delivery of alcohol behavioral couple therapy.

Journal of substance use and addiction treatment·2026

Same author

Greater Amyloid Burden in Cognitive Networks in Preclinical Alzheimer's Disease.

bioRxiv : the preprint server for biology·2026

Same author

Short-term intravenous fluids for prevention of post-ERCP pancreatitis (the STRIPE study): protocol for a five-arm randomised controlled trial.

BMJ open·2026

Same author

Immunoglobulin allotypes and <i>RELN</i> alleles and humoral immunity to HSV1 in patients with Alzheimer's disease and matched controls.

Journal of Alzheimer's disease : JAD·2026

Same author

The impact of a peer-mentoring intervention on self-reported flare and disease activity among African American women with Systemic Lupus Erythematosus (SLE).

Lupus·2026

Same author

Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.

Annals of the rheumatic diseases·2026

Search research articles

Related Experiment Video

Updated: May 18, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Racial differences between blacks and whites with systemic sclerosis.

Richard M Silver¹, Galina Bogatkevich, Elena Tourkina

¹Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. silverr@musc.edu

Current Opinion in Rheumatology

|September 8, 2012

Summary

This summary is machine-generated.

Racial disparities in systemic sclerosis (SSc) may stem from a genetic predisposition to fibrosis. Differences in profibrotic and antifibrotic factors, like TGF-β1, contribute to increased SSc severity in Black individuals.

More Related Videos

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

Related Experiment Videos

Last Updated: May 18, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

Area of Science:

Immunology
Genetics
Dermatology

Background:

Systemic sclerosis (SSc) disproportionately affects Black individuals, indicating a significant health burden.
Socioeconomic factors do not fully explain the observed racial disparities in SSc prevalence and mortality.

Purpose of the Study:

To investigate the potential biologic basis for racial disparities in systemic sclerosis (SSc).
To explore genetic and molecular factors contributing to SSc susceptibility and severity differences between racial groups.

Main Methods:

Comparative analysis of profibrotic and antifibrotic factor expression.
Examination of transforming growth factor-β1 (TGF-β1), caveolin-1, hepatocyte growth factor, and PPAR-γ expression.
Assessment of genetic predisposition to fibrosis in affected populations.

Main Results:

An imbalance of profibrotic and antifibrotic factors is implicated in increased SSc susceptibility and severity in Black individuals.
Racial differences in TGF-β1, caveolin-1, hepatocyte growth factor, and PPAR-γ expression were observed in Black individuals with SSc.
A genetic predisposition to fibrosis may significantly contribute to racial disparities in SSc.

Conclusions:

Understanding the biologic basis of SSc racial disparities is crucial for developing targeted therapies.
Therapeutic strategies for SSc may need to be adapted based on patient race and underlying biologic factors.