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Poststroke fatigue following minor infarcts: a prospective study.
Narges Radman1, Fabienne Staub, Tatiana Aboulafia-Brakha
1Department of Neurology, University of Fribourg, Fribourg, Switzerland.
Neurology
|September 8, 2012
Summary
Poststroke fatigue is common and linked to attentional-executive impairment, depression, and anxiety. These factors, not lesion site, are key predictors of developing fatigue after a stroke.
Area of Science:
- Neurology
- Psychiatry
- Rehabilitation Medicine
Background:
- Poststroke fatigue (PSF) is a prevalent and often debilitating condition affecting stroke survivors.
- Understanding the factors contributing to PSF is crucial for effective management and improving patient outcomes.
Purpose of the Study:
- To investigate the relationship between poststroke fatigue and mood, cognitive dysfunction, disability, and infarct location.
- To identify predictive factors for the development of PSF, particularly after minor strokes.
Main Methods:
- Ninety-nine patients with first, nondisabling strokes were assessed acutely and at 6 and 12 months post-stroke.
- Fatigue, mood, cognitive function, and disability were evaluated using validated instruments.
- Multivariate logistic regression analyzed variables predicting fatigue at 12 months based on acute-phase data.
Main Results:
- Fatigue was reported by 30.5% at 6 months and 34.7% at 12 months, with new cases emerging.
- Fatigue was significantly associated with reduced professional activity at both time points.
- Attentional-executive impairment, depression, and anxiety were consistently associated with PSF, while lesion site was not.
Conclusions:
- Attentional and executive dysfunction, depression, and anxiety are critical factors in the development of poststroke fatigue.
- These psychological and cognitive factors appear more influential than the physical location of the stroke lesion.
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