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Treatment of clomipramine-induced anorgasmia with yohimbine: a case report
1Department of Psychiatry, University of Michigan, Ann Arbor 48109-0118.
The Journal of Clinical Psychiatry
|January 1, 1990
Abstract:
Clomipramine (a tricyclic antidepressant with significant serotonin activity) causes a high incidence of anorgasmia. The authors describe the successful treatment of clomipramine-induced anorgasmia with yohimbine (an enhancer of norepinephrine activity) in a patient with obsessive compulsive disorder and major depression. The significance of this finding for the clinical management of antidepressant-induced sexual dysfunction and the impact of serotonergic-noradrenergic interaction on male sexual functioning are discussed.