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Evaluation of an attenuation correction method for PET/MR imaging of the head based on substitute CT images

Anne Larsson1, Adam Johansson, Jan Axelsson

  • 1Department of Radiation Sciences, Umeå University, 90187, Umeå, Sweden, anne.larsson.stromvall@vll.se.

Magma (New York, N.Y.)
|September 8, 2012
PubMed
Abstract

Insights

This study validates MR-based attenuation correction for PET imaging of the head, achieving high accuracy. While effective for brain imaging, precise quantification in the nasal septa region requires further refinement.

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • Accurate attenuation correction is crucial for quantitative PET imaging.
  • MR-based techniques offer a non-ionizing alternative to CT for attenuation correction.
  • Substitute CT (sCT) from MRI data is a promising approach.

Purpose of the Study:

  • To evaluate the accuracy of MR-based attenuation correction for head PET emission data.
  • To assess the performance of a novel sCT technique derived from MRI.
  • To compare PET/MRI-based attenuation correction with conventional PET/CT.

Main Methods:

  • Utilized (18)F-FLT PET/CT and MRI data from eight patients.
  • Calculated co-registered sCT images from MR data.
  • Reconstructed PET data using sCT and compared with CT-corrected data.
  • Evaluated the impact of bone-to-soft-tissue conversion in sCT.

Main Results:

  • Average relative differences between sCT- and CT-corrected PET images were 1.6% (head) and 1.9% (brain).
  • High standard deviation (13.2%) in the nasal septa region due to bone differences.
  • Lower standard deviation (4.1%) for brain regions.
  • Global average difference of 11% when bone was replaced by soft tissue in sCT.

Conclusions:

  • The MR-based attenuation correction method demonstrates high accuracy for head PET.
  • Quantitative imaging of the nasal septa region remains a challenge with the current sCT technique.
  • Further development is needed for precise nasal septa quantification.

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