Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Post-traumatic squamous-cell carcinoma.

R M Lifeso1, R J Rooney, M el-Shaker

  • 1King Faisel Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

The Journal of Bone and Joint Surgery. American Volume
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Translational psychiatry·2013
Same author

mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway.

Translational psychiatry·2013
Same author

Examination of the antibacterial properties of sphagnum moss (Sphagnum spp.) and its significance with turf burning in Ireland.

British journal of biomedical science·2013
Same author

Mining the antibiogram: what more can it tell us?

British journal of biomedical science·2012
Same author

Traffic accidents in Saudi Arabia: An epidemic.

Annals of Saudi medicine·2010
Same author

Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptide.

Genes and immunity·2010

Tumor grade significantly impacts metastasis risk in extremity squamous cell carcinoma. Poorly differentiated tumors (grades II and III) have a higher metastasis rate, necessitating aggressive treatment strategies.

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Squamous cell carcinoma (SCC) can arise in chronic scars or sinuses.
  • Metastasis to regional lymph nodes is a common complication.

Purpose of the Study:

  • To investigate prognostic factors for SCC arising in extremity scars.
  • To evaluate treatment outcomes for this rare malignancy.

Main Methods:

  • Retrospective analysis of 63 patients with SCC in extremity scars/sinuses (1976-1986).
  • Correlation of clinical factors (age, sex, etiology, duration) and tumor grade with metastasis and recurrence.
  • Evaluation of treatment modalities: wide local excision, amputation, lymph node resection, and prophylactic irradiation.

Main Results:

Related Experiment Videos

  • Tumor grade was the most significant prognostic factor: Grade I (10% metastasis), Grade II (59% metastasis), Grade III (86% metastasis).
  • Wide local excision and amputation showed variable success rates.
  • Radical lymph node resection post-metastasis was ineffective.
  • Prophylactic irradiation of regional lymph nodes in high-grade tumors showed promising results (1/10 metastasis).

Conclusions:

  • Tumor differentiation is a critical predictor of metastasis in scar-associated SCC.
  • Well-differentiated (Grade I) SCC should be classified as low-grade.
  • Poorly differentiated (Grades II and III) SCC should be considered high-grade, warranting aggressive management including consideration of prophylactic irradiation.