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Human lamina cribrosa insertion and age.

Ian A Sigal1, John G Flanagan, Kira L Lathrop

  • 1Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA. sigalia@upmc.edu.

Investigative Ophthalmology & Visual Science
|September 8, 2012
PubMed
Summary

The lamina cribrosa (LC) insertion into the pia mater is common in older eyes but does not increase with age. This study found a decrease in the fraction of LC inserting into the pia with advancing age.

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Area of Science:

  • Ophthalmology
  • Anatomy
  • Biomechanics

Background:

  • The lamina cribrosa (LC) is a crucial structure in the optic nerve head (ONH).
  • Its insertion into surrounding tissues, including the pia mater, may influence ocular biomechanics and vascularity.
  • Understanding age-related changes in LC insertion is important for ocular health.

Purpose of the Study:

  • To investigate the hypothesis that the lamina cribrosa (LC) insertion into the pia mater increases with age in healthy human eyes.
  • To quantify the relationship between age, intraocular pressure (IOP), and LC insertion characteristics.

Main Methods:

  • Optic nerve heads (ONHs) from 21 donor eyes (ages 47-91) were analyzed.
  • 3D models were reconstructed to measure LC insertion areas into the scleral flange and pia mater.

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  • Linear mixed-effect models assessed associations with age and IOP.

    • Main Results:

    • Lamina cribrosa (LC) insertion into the pia mater was observed in all analyzed eyes.
    • A significant decrease in the fraction of LC inserting into the pia was found with increasing age (P=0.049).
    • No significant association was found between LC insertion measures and intraocular pressure (IOP).

    Conclusions:

    • Lamina cribrosa (LC) insertion into the pia mater is a common finding in middle-aged and older eyes.
    • Contrary to the hypothesis, LC insertion into the pia does not increase with age.
    • Further research is needed to understand the biomechanical and vascular implications of LC-pia insertion.