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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Nanoparticle-based test measures overall propensity for calcification in serum.

Andreas Pasch¹, Stefan Farese, Steffen Gräber

¹Department of Nephrology and Hypertension, University Hospital and University of Bern, Inselspital, 3010 Bern, Switzerland. andreas.pasch@insel.ch

Journal of the American Society of Nephrology : JASN

|September 8, 2012

Summary

A new nanoparticle assay measures serum

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Area of Science:

Biochemistry
Nanotechnology
Clinical Chemistry

Background:

Vascular and soft tissue calcification is a significant contributor to cardiovascular morbidity and mortality.
Serum calcium and phosphate concentrations are close to supersaturation, making the balance of inhibitors and promoters crucial for calcification.
A clinical assay to measure the propensity for calcification in serum could be valuable.

Purpose of the Study:

To develop and describe a novel nanoparticle-based assay for measuring the intrinsic capacity of serum to inhibit calcification.
To assess the utility of this assay in identifying reduced calcification inhibition properties in specific conditions.

Main Methods:

A nanoparticle-based assay was developed to detect the transformation of primary calciprotein particles (CPPs) to secondary CPPs under elevated calcium and phosphate conditions.
The assay characterizes the transition of CPPs to quantify the serum's intrinsic ability to inhibit calcium and phosphate precipitation.

Main Results:

The developed assay successfully measured the propensity for calcification in serum.
Sera from fetuin-A deficient mice and hemodialysis patients exhibited reduced intrinsic calcification inhibition properties.
This indicates the assay can detect impaired calcification inhibition.

Conclusions:

A novel nanoparticle-based assay has been developed to measure the overall propensity for calcification in serum.
The assay shows potential for clinical use, particularly in identifying individuals with reduced calcification inhibition.
Further prospective studies are required to validate the clinical utility of this calcification propensity assay.