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Updated: May 18, 2026

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

Vertebral compression model and comparison of augmentation agents.

Clint Hill¹, Scott Wingerter, Doug Parsell

¹Department of Orthopedic Surgery and Rehabilitation, University of Mississippi Medical Center.

Evidence-Based Spine-Care Journal

|September 8, 2012

Summary

This study tested bone fillers for vertebral compression fractures using a sawbone model. Polymethylmethacrylate (PMMA) showed the highest stiffness, while SRS-tricalcium phosphate was closest to natural bone strength.

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Area of Science:

Biomedical Engineering
Orthopedic Research
Materials Science

Background:

Vertebral compression fractures are a significant clinical challenge.
Effective bone fillers are crucial for restoring vertebral strength and function.
Biomechanical testing models are essential for evaluating new bone augmentation materials.

Purpose of the Study:

To assess the compression strength of various bone fillers in a simulated osteoporotic vertebral body.
To determine the viability of a third-generation sawbone model for biomechanical evaluation of vertebral fillers.
To compare the mechanical properties of polymethylmethacrylate (PMMA), SRS-tricalcium phosphate, MIIGX3 HiVisc, and BoneSource.

Main Methods:

A biomechanical study using a third-generation osteoporotic sawbone model.

Related Experiment Videos

Last Updated: May 18, 2026

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

Cavities were created in sawbone vertebrae and filled with PMMA, SRS, MIIGX3 HiVisc, and BoneSource.

Cured fillers were tested to failure in compression, and elastic modulus was calculated and compared to an unaugmented control group.

Main Results:

The mean modulus of elasticity varied significantly among the tested bone fillers.
Polymethylmethacrylate (PMMA) exhibited the highest modulus of elasticity (195.47 ± 2.33 MPa), significantly higher than all other groups.
SRS-tricalcium phosphate (79.14 ± 20.20 MPa) and BoneSource (57.49 ± 8.35 MPa) showed moduli closer to the control group (92.44 ± 19.28 MPa), with SRS-tricalcium phosphate not significantly different from the control.

Conclusions:

The third-generation osteoporotic sawbone model effectively simulates in vitro vertebral function for biomechanical testing.
The model is suitable for comparing osteoconductive agents and their potential to minimize adjacent level fractures.
PMMA demonstrated increased stiffness, while calcium phosphate or calcium sulfate cements may offer a reduced risk of adjacent segment fractures compared to PMMA.