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Related Experiment Video

Updated: May 18, 2026

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
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Amyloid β-Related Angiitis Causing Coma Responsive to Immunosuppression.

Shennan A Weiss1, David Pisapia, Stephan A Mayer

  • 1Department of Neurology, Columbia University, 710 W. 168th Street, New York, NY 10032, USA.

Case Reports in Pathology
|September 8, 2012
PubMed
Summary

Amyloid-beta-related angiitis (ABRA) is a rare CNS vasculitis. Prompt diagnosis and aggressive immunosuppression, including steroids, can lead to significant neurological recovery in severe cases.

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Last Updated: May 18, 2026

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
10:19

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Published on: August 14, 2016

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion
03:37

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion

Published on: July 5, 2024

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Amyloid-beta-related angiitis (ABRA) is a CNS vasculitis triggered by perivascular beta-amyloid.
  • Inflammation involves CD68+ macrophages and CD3+ T lymphocytes.
  • Severe ABRA can manifest as coma, potentially responsive to immunosuppression.

Purpose of the Study:

  • To present a case of ABRA with severe neurological impairment.
  • To highlight the diagnostic pathway and treatment response.
  • To emphasize the importance of considering ABRA in specific clinical scenarios.

Main Methods:

  • Case presentation of a 57-year-old male with febrile obtundation and hemiparesis.
  • Diagnostic workup included CSF analysis and brain biopsy.
  • Treatment involved cyclophosphamide and steroids.

Main Results:

  • Brain biopsy confirmed amyloid angiopathy and perivascular lymphocytic infiltrate, indicative of ABRA.
  • The patient showed remarkable neurological improvement after one week of immunosuppressive therapy.
  • Significant recovery was observed over several weeks.

Conclusions:

  • ABRA presents with diverse neurological symptoms, including coma.
  • Accurate pathological diagnosis is crucial for initiating effective treatment.
  • Aggressive immunosuppression can lead to substantial neurological recovery in ABRA patients.