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Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: May 18, 2026

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation
09:09

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation

Published on: November 10, 2017

Cell cycle control in acute myeloid leukemia.

Dominik Schnerch1, Jasmin Yalcintepe, Andrea Schmidts

  • 1Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Germany.

American Journal of Cancer Research
|September 8, 2012
PubMed
Summary

Acute myeloid leukemia (AML) involves uncontrolled cell cycles in hematopoietic precursor cells (HPCs), leading to mutations and resistance to cell death. Understanding cell cycle deregulation offers new therapeutic strategies for AML.

Keywords:
Acute myeloid leukemia (AML)cell cycledifferentiationgenetic instabilityproliferation

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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Area of Science:

  • Hematology
  • Cancer Biology
  • Molecular Oncology

Background:

  • Acute myeloid leukemia (AML) arises from hematopoietic precursor cells (HPCs) undergoing malignant transformation.
  • This transformation involves uncontrolled cell proliferation and resistance to apoptosis.
  • Genomic instability is a key feature, promoting clone adaptation and survival.

Purpose of the Study:

  • To review the role of deregulated cell cycle control in AML pathogenesis.
  • To explore the link between proliferation, differentiation, and leukemogenesis.
  • To discuss the therapeutic implications of understanding cell cycle regulation in AML.

Main Methods:

  • Literature review focusing on cell cycle regulation in AML.
  • Analysis of the connection between cell differentiation and proliferation.
  • Examination of the impact of specific genetic alterations on therapeutic response.

Main Results:

  • Deregulated cell cycle control drives increased proliferation and genomic instability in AML.
  • Altered cell cycle progression favors the acquisition of mutations and leukemic transformation.
  • Specific cell cycle alterations influence patient response to therapy.

Conclusions:

  • Understanding cell cycle deregulation is crucial for AML pathogenesis.
  • Targeting cell cycle pathways presents promising therapeutic strategies for AML.
  • Further research into cell cycle regulation can improve AML treatment outcomes.