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Updated: May 18, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
Painful procedures in the NICU
S M Vitaliti1, G Costantino, L Li Puma
1Neonatology Unit, NICU and Creche, ARNAS Civico-Di Cristina-Ascoli, Palermo, Italy. marcello.vitaliti@alice.it
This study investigates sucrose as a pain reliever for newborns during common medical procedures. Results aim to improve pain management for neonates undergoing venipuncture and heel punctures.
Area of Science:
- Neonatal care
- Pain perception in infants
- Pediatric analgesia
Background:
- Neonatal intensive care units (NICUs) frequently involve painful procedures.
- Effective pain management in newborns is crucial for development.
- Existing literature highlights the need for better neonatal pain control strategies.
Purpose of the Study:
- To evaluate the analgesic efficacy of different sucrose concentrations.
- To assess sucrose's effectiveness during venipuncture and heel punctures in term neonates.
- To provide evidence-based recommendations for neonatal pain management.
Main Methods:
- A double-blind study design was employed.
- The study involved term neonates in a neonatal intensive care unit.
- Three different concentrations of sucrose were tested for analgesia during venipuncture and heel puncture.
Main Results:
- The study is ongoing since February 2012.
- Data collection focuses on pain responses during specific procedures.
- Analysis will compare the effectiveness of varying sucrose concentrations.
Conclusions:
- Sucrose shows promise as a non-pharmacological analgesic for neonates.
- Optimizing sucrose concentration can enhance pain relief during common neonatal procedures.
- Findings will contribute to improved pain management protocols in NICUs.
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