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Updated: May 18, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Painful procedures in the NICU.

S M Vitaliti¹, G Costantino, L Li Puma

¹Neonatology Unit, NICU and Creche, ARNAS Civico-Di Cristina-Ascoli, Palermo, Italy. marcello.vitaliti@alice.it

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|September 11, 2012

Summary

This study investigates sucrose as a pain reliever for newborns during common medical procedures. Results aim to improve pain management for neonates undergoing venipuncture and heel punctures.

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Electrophysiological Measurements and Analysis of Nociception in Human Infants

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

Area of Science:

Neonatal care
Pain perception in infants
Pediatric analgesia

Background:

Neonatal intensive care units (NICUs) frequently involve painful procedures.
Effective pain management in newborns is crucial for development.
Existing literature highlights the need for better neonatal pain control strategies.

Purpose of the Study:

To evaluate the analgesic efficacy of different sucrose concentrations.
To assess sucrose's effectiveness during venipuncture and heel punctures in term neonates.
To provide evidence-based recommendations for neonatal pain management.

Main Methods:

A double-blind study design was employed.
The study involved term neonates in a neonatal intensive care unit.
Three different concentrations of sucrose were tested for analgesia during venipuncture and heel puncture.

Main Results:

The study is ongoing since February 2012.
Data collection focuses on pain responses during specific procedures.
Analysis will compare the effectiveness of varying sucrose concentrations.

Conclusions:

Sucrose shows promise as a non-pharmacological analgesic for neonates.
Optimizing sucrose concentration can enhance pain relief during common neonatal procedures.
Findings will contribute to improved pain management protocols in NICUs.