Related Experiment Video
Updated: May 18, 2026
10:19
Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
Published on: April 8, 2017
Current status and future perspectives for sequencing livestock genomes
Yongsheng Bai1, Maureen Sartor, James Cavalcoli
1Center for Computational Medicine and Bioinformatics and Department of Computational Medicine and Bioinformatics, The University of Michigan, 100 Washtenaw Ave,, 2017 Palmer Commons, Ann Arbor, Michigan 48109-2218, USA. ybai@umich.edu.
Journal of Animal Science and Biotechnology
|September 11, 2012
Summary
Next-generation sequencing (NGS) advances agricultural research by enabling genome analysis in livestock. This technology helps identify genes influenced by environment, accelerating genetic improvement and disease prevention for efficient animal production.
Area of Science:
- Agricultural Science
- Genomics
- Animal Breeding
Background:
- Genome sequencing in agricultural animals is a recent development.
- Genetic comparisons are crucial for understanding animal performance differences.
Purpose of the Study:
- To review the current status of agricultural animal genome sequencing.
- To highlight the benefits of next-generation sequencing (NGS) for agricultural research.
Main Methods:
- Review of current agricultural animal genome sequencing projects.
- Discussion of the capabilities of next-generation sequencing (NGS) technologies.
Main Results:
- NGS offers decreased costs and increased speed for genome sequencing.
- NGS can identify genes and chromosomal regions sensitive to environmental factors.
- NGS facilitates the study of animal responses to environmental models, such as nutrition.
Conclusions:
- NGS accelerates genetic improvement by revealing key genes and gene-environment interactions.
- NGS technologies assist in efficient animal husbandry and infectious disease prevention.
- Implementing NGS can lead to decreased animal production costs.
Related Concept Videos
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
01:57Sanger Sequencing
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
02:51Multi-species Conserved Sequences
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
01:05Maxam-Gilbert Sequencing
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
Challenges of the Maxam-Gilbert Method
The...
01:29Modern Molecular Taxonomy
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...