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Published on: July 19, 2024
WAAR (World Alliance against Antibiotic Resistance): Safeguarding antibiotics
Jean Carlet1, Claude Rambaud, Céline Pulcini
1WAAR, 9 rue de la Terrasse, 94000, Creteil, France. jeancarlet@gmail.com.
Summary:
Resistance to antibiotics has increased recently to a dramatic extend, and the pipeline of new antibiotics is almost dry for the five next years. Failures happen already for trivial community acquired infections, like pyelonephritis, or peritonitis, and this is likely to increase. Difficult surgical procedures, transplants, and other immunosuppressive therapies will become far more risky. Resistance is mainly due to an excessive usage of antibiotics, in all sectors, including the animal one. Action is urgently needed. Therefore, an alliance against MDRO has been recently created, which includes health care professionals, consumers, health managers, and politicians. The document highlights the different proposed measures, and represents a strong consensus between the different professionals, including general practicionners, and veterinarians.
Insights
Antibiotic resistance is a growing crisis with a limited new drug pipeline. Urgent action is needed through a new alliance to combat multidrug-resistant organisms (MDROs).
Area of Science:
- Microbiology and Infectious Diseases
- Public Health Policy
- One Health Approach
Background:
- Escalating antibiotic resistance poses a significant threat to global health.
- The pipeline for novel antibiotics is critically depleted, exacerbating the crisis.
- Current antibiotic usage, including in animal agriculture, drives resistance development.
Discussion:
- Multidrug-resistant organisms (MDROs) are causing treatment failures in common infections.
- Complex medical procedures and immunosuppressive therapies are increasingly jeopardized.
- Excessive antibiotic consumption across human and animal sectors is the primary driver.
Key Insights:
- A new alliance uniting healthcare professionals, consumers, policymakers, and veterinarians has formed.
- This alliance aims to implement coordinated strategies against MDROs.
- A strong consensus exists among diverse stakeholders on the urgency and proposed measures.
Outlook:
- Immediate, collaborative action is imperative to mitigate the impact of antibiotic resistance.
- The alliance seeks to foster responsible antibiotic stewardship and develop new interventions.
- Addressing MDROs requires a unified approach across all societal sectors.
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