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Related Experiment Video

Updated: May 18, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Skin involvement in cutaneous and systemic vasculitis.

Angelo V Marzano¹, Pamela Vezzoli, Emilio Berti

¹U.O. Dermatologia, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Milan, Italy.

Autoimmunity Reviews

|September 11, 2012

Summary

Cutaneous vasculitides are diverse inflammatory skin blood vessel disorders. This review covers common types like small vessel vasculitis and urticarial vasculitis, plus related conditions.

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Area of Science:

Dermatology
Rheumatology
Immunology

Background:

Cutaneous vasculitides encompass inflammatory conditions affecting skin blood vessels.
Triggers include infections, drugs, or underlying diseases like connective tissue disorders or malignancies.
In some cases, vasculitis occurs without identifiable causes, and skin lesions may be the initial or sole manifestation.

Purpose of the Study:

To review the most common variants of cutaneous vasculitis.
To discuss related conditions and cutaneous manifestations of systemic vasculitides.
To provide an overview of diagnostic considerations for cutaneous vasculitis.

Main Methods:

Literature review focusing on common cutaneous vasculitis types.
Analysis of associated conditions and systemic vasculitis manifestations.
Discussion of diagnostic approaches, including vasculitis as a diagnosis of exclusion.

Main Results:

Common variants include cutaneous small vessel vasculitis and urticarial vasculitis.
Henoch-Schönlein purpura, though systemic, often presents with predominant skin involvement.
Livedoid vasculopathy, frequently linked to connective tissue disease, is discussed despite not being overtly vasculitic.
Cutaneous manifestations of systemic vasculitides like Wegener's granulomatosis, Churg-Strauss syndrome, and polyarteritis nodosa are analyzed.

Conclusions:

Cutaneous vasculitis is a complex group of disorders with varied etiologies and presentations.
Accurate diagnosis often requires considering vasculitis as a diagnosis of exclusion and recognizing its association with systemic diseases.
This review highlights key variants and related conditions, aiding in understanding and managing these dermatologic manifestations.