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Updated: May 18, 2026
Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
The value of chromosomal analysis in oligozoospermic men
Çarcia Stegen1, Minouche M E van Rumste, Ben Willem J Mol
1Department of Obstetrics and Gynecology, Maxima Medical Center, Veldhoven, The Netherlands. stegencarcia@gmail.com
Objective:
To determine the prevalence of chromosomal abnormalities in relation to sperm concentration in subfertile oligozoospermic men.
Design:
Retrospective cohort study.
Setting:
Two teaching hospitals.
Patient(S):
We retrospectively studied all men who received chromosomal analysis prior to intracytoplasmic sperm injection (ICSI) treatment from 2000 to 2010 in two teaching hospitals.
Intervention(S):
None.
Main Outcome Measure(S):
The results of chromosomal analysis and semen analysis were recorded. The frequency of abnormal karyotypes was analyzed in relation to the sperm concentration, categorized as extreme oligozoospermia (>0 to ≤1 million/mL), severe oligozoospermia (>1 to ≤5 million/mL), moderate oligozoospermia (>5 to ≤20 million/mL), or normospermia (>20 million/mL).
Result(S):
Among 582 male ICSI candidates, the rates of abnormal karyotypes were 1.2% (2/162), 2.2% (5/227), and 1.5% (2/130) for men with extreme, severe, and moderate oligozoospermia, respectively. No abnormalities were present in normospermic men.
Conclusion(S):
The risk of conceiving a viable child with unbalanced structural chromosomal abnormalities in men with oligozoospermia may not justify karyotyping.
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