Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deciphering and Targeting the Schwannoma-Neuron-Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Burn injury induces systemic inflammation and neuroinflammation with neurobehavioral sequalae in mice.

Burns : journal of the International Society for Burn Injuries·2026

Same author

Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation.

Frontiers in pharmacology·2025

Same author

Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain†.

Pain medicine (Malden, Mass.)·2025

Same author

Pathophysiology and management of burn injury-induced pain.

Burns open : an international open access journal for burn injuries·2025

Same author

The design and rationale of the Biomarkers for Evaluating Spine Treatments trial: a sequential multiple assignment randomized trial.

Pain medicine (Malden, Mass.)·2025

Search research articles

Related Experiment Video

Updated: May 18, 2026

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

Current challenges in translational pain research.

¹MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. jmao@partners.org

Trends in Pharmacological Sciences

|September 11, 2012

Summary

This summary is machine-generated.

Developing new pain relief drugs faces hurdles because animal pain models and clinical trials don't fully capture complex chronic pain. A new approach is needed to study pain as a system, including psychological factors.

More Related Videos

Development of Recombinant Proteins to Treat Chronic Pain

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Related Experiment Videos

Last Updated: May 18, 2026

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Published on: April 21, 2023

Development of Recombinant Proteins to Treat Chronic Pain

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Area of Science:

Pain Medicine
Translational Research
Analgesic Development

Background:

Significant gap exists between basic science discoveries and the development of novel analgesics.
Current preclinical models fail to adequately represent the complexity of human chronic pain conditions.
Existing clinical trial designs often overlook the multifaceted nature of comorbid chronic pain.

Purpose of the Study:

To highlight the challenges in current translational pain research for analgesic development.
To advocate for a paradigm shift in how pain is studied and treated.
To discuss key issues hindering effective pain medicine innovation.

Main Methods:

Review of current limitations in animal pain models and behavioral testing.
Analysis of shortcomings in preclinical data translation to clinical efficacy.
Examination of clinical trial methodologies and their impact on capturing comorbid pain consequences.

Main Results:

Animal models do not simulate multidimensional clinical pain or subjective experiences.
Preclinical data offer limited predictive value for new analgesic development.
Clinical trials often use oversimplified populations, missing the impact of psychosocial factors.

Conclusions:

A paradigm shift is essential, moving from molecular nociception to a systems-based approach to pain.
Future research must integrate psychosocial comorbidities into pain research strategies.
Rethinking translational pain research is crucial for advancing pain medicine.