Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tier-specific location of Lewy body pathology and related neuromelanin levels drive dopaminergic cell vulnerability in pigmented non-human primates.

Neurobiology of disease·2026
Same author

Safety and efficacy of staged, bilateral magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for motor complications of Parkinson's disease: a prospective, multicentre, single-arm trial.

The Lancet. Neurology·2026
Same author

MRI mapping of nigrostriatal pathway degeneration in early-stage Parkinson's disease.

Neurobiology of disease·2026
Same author

Taurine and MAO B binding sites in the brain of monkeys determine differing responses to MPTP administration.

Journal of neuroscience methods·2026
Same author

Noninvasive Focal Gene Delivery into the Cerebellum of Non-Human Primates using Focused Ultrasound.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Five-Year Follow-Up of Unilateral Focused Ultrasound Subthalamotomy for Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026
Same journal

Thyrotropin-releasing hormone and dopaminergic systems interact in the ventral tegmental area to regulate food intake in rats.

Neuropharmacology·2026
Same journal

TRPC5 as a modulator of TRPV1 signalling in pathological pain states.

Neuropharmacology·2026
Same journal

Loss of mGlu<sub>5</sub> receptors from PV inhibitory neurons attenuates sex differences in ethanol and sucrose seeking.

Neuropharmacology·2026
Same journal

PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain.

Neuropharmacology·2026
Same journal

Purinergic-cytokine signaling as a regulatory axis in neuroimmune development.

Neuropharmacology·2026
Same journal

Acupuncture improves depressive symptoms and prefrontal cortical function in mild to moderate depressive disorder: A randomized sham-controlled trial and fNIRS study.

Neuropharmacology·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Striatal interaction among dopamine, glutamate and ascorbate.

Ingrid Morales1, Angel Fuentes, Santiago Ballaz

  • 1Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain.

Neuropharmacology
|September 11, 2012
PubMed
Summary
This summary is machine-generated.

This study reveals complex interactions between glutamate, dopamine, and ascorbic acid in rat brains. These neurotransmitter dynamics in the striatum differ from the substantia nigra, impacting basal ganglia disorder treatments.

More Related Videos

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Related Experiment Videos

Last Updated: May 18, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Area of Science:

  • Neuroscience
  • Neurochemistry

Background:

  • The interplay between glutamate (GLU), dopamine (DA), and ascorbic acid (AA) in the striatum is crucial but often studied in isolation.
  • Understanding these interactions is key to exploring treatments for basal ganglia disorders.

Purpose of the Study:

  • To quantify the extracellular interactions among GLU, DA, and AA in the rat striatum using microdialysis.
  • To compare these striatal interactions with those in the substantia nigra (SN).

Main Methods:

  • Utilized microdialysis in rats to measure extracellular concentrations of GLU, DA, and AA.
  • Administered GLU, DA, and AA via reverse microdialysis to observe their effects on each other and metabolites like DOPAC.
  • Compared findings in the striatum with those in the substantia nigra.

Main Results:

  • In the striatum, GLU perfusion increased DA and decreased DOPAC; DA perfusion decreased GLU and glutamine (likely via D2 receptors); AA perfusion increased DA and decreased DOPAC.
  • In the SN, GLU perfusion increased both DA and DOPAC.
  • Striatal findings suggest GLU-release inhibits DA-uptake, DA-release inhibits GLU-release, and AA-release prevents DA-oxidation.

Conclusions:

  • A significant GLU-DA-AA interaction exists in the striatum, with distinct mechanisms compared to the SN.
  • These findings highlight potential therapeutic targets for basal ganglia disorders by modulating these neurotransmitter systems.