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Updated: May 18, 2026
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Sensitive detection of rutin with novel ferrocene benzyne derivative modified electrodes
Meiling Liu1, Jianhui Deng, Qiong Chen
1Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
Abstract:
A new ferrocene benzyne derivative (Fc-SAc) that contained oligo-(phenylene-ethynylene) skeleton, ferrocene and thiolate terminal groups was firstly synthesized. The hydrolysis product of Fc-SAc (Fc-SH) was immobilized onto gold nanoparticles (AuNPs) modified glass carbon electrode (GCE) as sensing element for rutin detection with high sensitivity. The new sensing strategy was proposed by using two Fc-SH modified electrodes: Fc-S/AuNPs/GCE (Electrode1) and Fc-S/AuNPs/graphene-chitosan/GCE (Electrode2). The electrochemical oxidation of rutin on Electrode2 was a diffusion-controlled process, which was different from a mass-controlled process on Electrode1. Under the optimal conditions, the peak currents of the sensors were linearly related to the concentrations of rutin. The linear responses ranges were 0.05-30 μM and 0.04-100 μM with the regression coefficients of 0.998 and 0.997 on Electrode1 and Electrode2, respectively. Electrode2 presented wider linear range, superior high sensitivity, lower detection limit and better stability on determination of rutin.
