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Published on: August 11, 2008

Hearing loss in children treated for multidrug-resistant tuberculosis

James A Seddon1, Stephanie Thee, Kayleen Jacobs

  • 1Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa. jseddon@sun.ac.za

The Journal of Infection
|September 11, 2012
PubMed

Insights

Hearing loss is a common side effect in children treated for multidrug-resistant tuberculosis (MDR-TB) with injectable drugs. This study found 24% of children experienced hearing loss, with some cases worsening after treatment completion.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Otolaryngology

Background:

  • Aminoglycosides and polypeptides are crucial for treating multidrug-resistant tuberculosis (MDR-TB).
  • These drug classes are known to cause hearing loss as a significant side effect.
  • The impact of these treatments on pediatric hearing is not fully understood.

Purpose of the Study:

  • To investigate the prevalence and extent of hearing loss in children undergoing treatment for MDR-TB.
  • To identify potential risk factors associated with hearing loss in this pediatric population.

Main Methods:

  • A retrospective study was conducted on children under 15 years old treated for MDR-TB with injectable drugs between January 2009 and December 2010.
  • Hearing assessments were performed using audiometry and otoacoustic emissions.
  • Data on HIV status and TB diagnosis confirmation were collected.

Main Results:

  • Out of 94 children included, 23% (24%) experienced hearing loss.
  • A culture-confirmed diagnosis of TB was a significant risk factor for hearing loss (OR: 4.12).
  • Progression of hearing loss was observed in 64% of children assessed by audiometry after completing injectable drug therapy.

Conclusions:

  • Hearing loss is a frequent complication in children treated for MDR-TB.
  • The findings underscore the need for alternative treatment options for pediatric MDR-TB to mitigate ototoxicity.
Abstract

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