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Updated: May 18, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
Polarity and stratification of the epidermis
Andrew Muroyama1, Terry Lechler
1Department of Cell Biology, Duke University Medical Center, USA.
Abstract:
Polarity is a fundamental property of epithelial cells. In this review, we discuss our current knowledge of the polarity of a stratified epithelium, the epidermis, focusing on similarities and differences with simple epithelial models. We highlight how the differences in tissue architecture and physiology result in alterations in some aspects of cell polarity. In addition, we discuss one of the most prominent uses for cell polarity in the epidermis-orienting the mitotic spindle to drive the stratification and differentiation of this tissue during development.
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