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Updated: May 18, 2026
09:10
Generation of 3-D Collagen-based Hydrogels to Analyze Axonal Growth and Behavior During Nervous System Development
Published on: June 25, 2019
Collagen--emerging collagen based therapies hit the patient
Ensanya A Abou Neel1, Laurent Bozec, Jonathan C Knowles
1King Abdulaziz University, Conservative Dental Science Department, Biomaterials Division, Saudi Arabia. abouneel@kau.edu.sa
Advanced Drug Delivery Reviews
|September 11, 2012
Summary
Collagen biomaterials, derived from natural or synthetic sources, offer promising scaffolds for regenerative medicine. Advanced techniques create sophisticated 3D collagen structures for diverse clinical applications, including tissue repair and regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Collagen is a key mammalian protein, abundant and essential for life.
- Naturally derived collagen extracellular matrices (ECMs) are established surgical materials.
- New biomaterials constantly emerge, seeking to improve upon existing options.
Purpose of the Study:
- To review naturally and synthetically produced collagen matrices for regenerative medicine.
- To discuss advanced fabrication of 3D collagen scaffolds using plastic compression technology.
- To highlight current and potential applications of collagen-based products.
Main Methods:
- In-depth review of literature on collagen biomaterials.
- Discussion of ECM processing for clinical use.
- Exploration of plastic compression technology for scaffold fabrication.
Main Results:
- Collagen offers a biomimetic scaffold for regenerative medicine.
- Advanced 3D collagen scaffolds can be engineered with controlled structures.
- Various collagen products are available for neural repair, cosmetics, hemostasis, wound healing, and bone regeneration.
Conclusions:
- Collagen biomaterials are versatile for regenerative medicine.
- Sophisticated collagen scaffolds show potential for enhanced therapeutic outcomes.
- Ongoing research continues to expand the applications of collagen in medicine.
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For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
01:13Collagens are the Major Structural Proteins of ECM
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Connective tissue proper includes loose...
Connective tissue proper includes loose...
01:23Tissue Renewal without Stem Cells
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A type IV collagen molecule has six alpha chains which can exist in...
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