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A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization
P A Broliden1, K Ljunggren, J Hinkula
1Department of Virology, Karolinska Institute, Stockholm, Sweden.
Journal of Virology
|February 1, 1990
Abstract:
Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other MAbs with a similar epitopic reactivity did not show any antibody-dependent cellulan cytotoxicity activity but had a virus-neutralizing capacity.