Related Experiment Video
Updated: May 18, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
Sternocostal involvement in chronic recurrent multifocal osteomyelitis associated with ulcerative colitis
Yun Sung Kim1, Jun Lee, Hyun-Sook Kim
1Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Chosun University of Korea, 588 Seoseok-dong, Dong-gu, Gwangju, 501-717, Republic of Korea.
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare inflammatory bone disorder. This case highlights sternocostal involvement in CRMO associated with ulcerative colitis, emphasizing the need for early diagnosis.
Area of Science:
- Rheumatology
- Pediatric Rheumatology
- Gastroenterology
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, chronic, inflammatory, non-infectious skeletal disorder of unknown etiology.
- CRMO can manifest as an extraintestinal rheumatic manifestation in patients with inflammatory bowel disease.
- CRMO associated with ulcerative colitis (UC) is exceptionally uncommon.
Related Concept Videos
Inflammatory Bowel Disease II: Ulcerative Colitis
Inflammatory Bowel Disease III: Crohn's Disease
Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Ulcerative Colitis in IBD
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.