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Related Experiment Videos

Transcriptome alterations induced by cigarette smoke.

Jerome S Brody1

  • 1Boston University School of Medicine, Pulmonary Center (R-3), Boston, MA 02118, USA. jbrody@bu.edu

International Journal of Cancer
|September 11, 2012
PubMed
Summary
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Cigarette smoke significantly changes gene expression across many tissues, increasing inflammation and cancer-related genes. Understanding these transcriptomic alterations offers new avenues for personalized prevention and treatment of smoking-related diseases.

Area of Science:

  • Molecular biology
  • Genomics
  • Cancer research

Background:

  • Cigarette smoke impacts gene expression in various tissues, both directly exposed and indirectly affected by its components.
  • Smoking-induced transcriptomic changes include upregulation of antioxidant, xenobiotic, inflammation, and oncogenic genes.
  • Smoking is a known risk factor for cancers in multiple organs, including lungs, bladder, liver, and pancreas.

Purpose of the Study:

  • To explore the complex transcriptomic alterations induced by cigarette smoke exposure.
  • To understand the variability in individual responses to smoking based on genetic factors and smoking habits.
  • To investigate the concept of a genomic "field of injury" in cells exposed to tobacco products.

Main Methods:

  • Analysis of transcriptomic changes in various tissues affected by cigarette smoke.

Related Experiment Videos

  • Utilizing whole genome sequencing and next-generation sequencing technologies.
  • Examining both tumor and cytologically normal cells from individuals exposed to cigarette smoke.

    • Main Results:

    • Identified widespread alterations in gene expression profiles across multiple tissues due to smoking.
    • Observed increased expression of genes involved in antioxidant defense, xenobiotic metabolism, inflammation, and oncogenesis.
    • Highlighted significant individual variability in transcriptomic responses to smoking.

    Conclusions:

    • Cigarette smoke induces a complex and variable transcriptomic response, contributing to smoking-related cancers.
    • Transcriptomic and genomic studies are crucial for unraveling the mechanisms behind smoking-induced pathologies.
    • Next-generation sequencing offers potential for developing personalized prevention and treatment strategies for smoking-related diseases.