Related Experiment Video
Updated: Aug 11, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
Bleeding complications in pediatric ABO-incompatible kidney transplantation
Betti Schaefer1, Burkhard Tönshoff, Jan Schmidt
1Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Pediatric Nephrology (Berlin, Germany)
|September 11, 2012
Summary
Pediatric ABO-incompatible kidney transplants (ABOi-RTx) are feasible using immunoadsorption (IA) and rituximab preconditioning. Bleeding complications require careful management, likely due to IA
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- ABO-incompatible renal transplantation (ABOi-RTx) with immunoadsorption (IA) and rituximab shows promise for living-related transplants.
- Clinical data in pediatric patients undergoing ABOi-RTx is limited.
Purpose of the Study:
- To evaluate the safety and efficacy of ABOi-RTx in pediatric patients using IA and rituximab preconditioning.
Main Methods:
- Three pediatric patients underwent living-related ABOi-RTx.
- Preoperative IA (6-11 sessions) and a single dose of rituximab were administered to reduce isoagglutinin titers.
- Standard quadruple immunosuppression (tacrolimus, mycophenolate, methylprednisolone, basiliximab) and IVIg were used.
Main Results:
- All patients achieved normal renal function within 2-6 days post-transplant.
- Two patients experienced major bleeding complications, one requiring surgical revision.
- One patient developed acute humoral rejection due to elevated isoagglutinin titers, successfully treated with plasma exchange and steroids.
Conclusions:
- ABOi-RTx is achievable in pediatric patients with IA and rituximab preconditioning.
- Bleeding complications are a significant concern, potentially linked to IA's effect on coagulation factors.
Related Concept Videos
02:45Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:15Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...