Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac chemical constant. Part II: Application to normal and abnormal left ventricular function.

C A Phillips1

  • 1Department of Biomedical Engineering, Wright State University, Dayton, OH 45435.

Journal of Biomedical Engineering
|January 1, 1990
PubMed
Summary

This study introduces cardiac chemical equilibrium dissociation constant (KD) to measure sarcomere length changes in heart conditions. Decompensated volume overload significantly alters this ratio, indicating impaired cardiac function during systole.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood acid/base balance in poultry: Dietary, environmental, and physiological determinants and emerging diagnostic opportunities.

Poultry science·2026
Same author

Coccidiosis in chickens: From temporal patterns of Lesion development and Oocyst shedding to predictive modeling.

Poultry science·2025
Same author

Dynamic responses of blood metabolites to nutrient depletion and repletion in broiler chicken nutrition.

Poultry science·2024
Same author

Systemic mastocytosis and probable mast cell leukaemia in a koala (Phascolarctos cinereus).

Australian veterinary journal·2020
Same author

Baseline morphometric, haematological and plasma biochemical parameters in free-ranging eastern water dragons (Intellagama lesueurii lesueurii).

Australian veterinary journal·2018
Same author

Sex identification in the eastern blue-tongued lizard (Tiliqua scincoides White, ex Shaw, 1790) using morphometrics.

Australian veterinary journal·2016

Area of Science:

  • Cardiovascular Physiology
  • Biophysics
  • Cardiac Mechanics

Background:

  • Cardiac function relies on sarcomere length dynamics.
  • Understanding these dynamics in various heart conditions is crucial for diagnosis and treatment.

Purpose of the Study:

  • To define and compute a novel physiochemical parameter, the cardiac chemical equilibrium dissociation constant (KD).
  • To analyze KD variations across the cardiac cycle in normal individuals and patients with different cardiac overload conditions.

Main Methods:

  • Defined KD as the ratio of long (extended) to short (contracted) sarcomeres.
  • Calculated KD at end-diastole (KDED), mid-systole (KDMC), and end-systole (KDES).
  • Assessed KD in normal subjects and patients with compensated/decompensated volume overload, compensated pressure overload, and congestive cardiomyopathy.

Related Experiment Videos

Main Results:

  • Normal KD values were established: KDED=2.47, KDMC=0.67, KDES=0.24.
  • No significant KD changes were observed in compensated volume overload compared to normal.
  • Decompensated volume overload showed a reduced KDMC/KDED ratio, indicating altered sarcomere interconversion.
  • Compensated pressure overload exhibited higher KDED and lower KDES, suggesting compensatory myocardial adaptations.

Conclusions:

  • The cardiac chemical equilibrium dissociation constant (KD) provides a quantitative measure of sarcomere dynamics.
  • KD alterations reflect specific pathophysiological changes in various cardiac conditions, particularly in pressure and volume overload.
  • The findings highlight the utility of KD in understanding myocardial adaptation and dysfunction.