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High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active
Sigalit Meker1, Katrin Margulis-Goshen, Ester Weiss
1Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Angewandte Chemie (International Ed. in English)
|September 11, 2012
Abstract:
A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan-Ti(IV) complex shows high antitumor activity, which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti(IV) can provide high cytotoxicity with controlled biological function.