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Related Experiment Videos

A rare cause of lower GI bleeding.

Mohammad Waleed1, A Mohamed Ali, Othman Saraj

  • 1Department of Gastroenterology, Scarborough General Hospital, North Yorkshire, UK. waleed1280@yahoo.com

BMJ Case Reports
|September 11, 2012
PubMed
Summary

A rare case of lower gastrointestinal bleeding caused by amyloidosis, a complication of multiple myeloma, is presented. This finding highlights the importance of considering myeloma in patients with unexplained GI bleeding.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Oncology

Background:

  • Multiple myeloma is a plasma cell malignancy that can lead to amyloidosis.
  • Amyloidosis is a condition where abnormal proteins build up in organs, potentially causing dysfunction.
  • Gastrointestinal involvement in amyloidosis, though rare, can manifest as bleeding.

Observation:

  • A 79-year-old female presented with a four-week history of bloody diarrhea.
  • Flexible sigmoidoscopy revealed mild inflammation of the sigmoid colon mucosa.
  • Abdominal CT scan identified lytic lesions in the vertebral bodies.

Findings:

  • Diagnostic tests, including 24-hour urine protein analysis and serum electrophoresis, indicated multiple myeloma.
  • A bone marrow biopsy confirmed the diagnosis of plasma cell myeloma.

Related Experiment Videos

  • The patient's lower gastrointestinal bleeding was attributed to amyloidosis secondary to multiple myeloma.

    • Implications:

    • This case underscores the significance of investigating multiple myeloma in patients presenting with lower gastrointestinal hemorrhage.
    • Recognizing GI amyloidosis as a complication of multiple myeloma is crucial for accurate diagnosis and management.
    • Early identification and treatment of multiple myeloma can potentially prevent or mitigate gastrointestinal complications.