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Migraine and genetic polymorphisms: an overview
Vincenzo Pizza1, Anella Agresta, Antonio Agresta
1Neurophysiopathology Service, S. Luca Hospital, Vallo della Lucania (SA), Italy.
The Open Neurology Journal
|September 11, 2012
Abstract:
The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.