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Cord blood chemerin and obestatin levels in large for gestational age infants

Theodora Boutsikou1, Despina D Briana, Maria Boutsikou

  • 1Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University, Medical School, Athens, Greece.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|September 12, 2012
PubMed

Insights

Cord blood chemerin levels are higher in large for gestational age (LGA) neonates, potentially indicating increased adipose tissue. Obestatin levels did not differ, suggesting metabolic disorder risks may emerge later in life.

Area of Science:

  • Endocrinology
  • Neonatal Metabolism
  • Adipose Tissue Biology

Background:

  • Adipokines like chemerin and obestatin are linked to insulin resistance and metabolic syndrome.
  • Large for gestational age (LGA) neonates have distinct body fat mass and metabolic profiles compared to appropriate for gestational age (AGA) neonates.

Purpose of the Study:

  • To compare cord blood levels of adipokines (chemerin, obestatin) and insulin between LGA and AGA neonates.
  • To investigate potential early indicators of metabolic alterations in LGA infants.

Main Methods:

  • Prospective measurement of cord blood chemerin, obestatin, and insulin concentrations.
  • Study included 40 LGA and 40 AGA singleton full-term infants.

Main Results:

  • Cord blood chemerin concentrations were significantly higher in LGA neonates compared to AGA neonates (p < 0.001).
  • No significant difference in cord blood obestatin concentrations was found between LGA and AGA groups.
  • Insulin levels showed a significant positive correlation with customized centiles (p = 0.032).

Conclusions:

  • Elevated chemerin in LGA neonates may reflect increased fetal adipose tissue.
  • The lack of difference in obestatin, a marker for insulin resistance, suggests metabolic issues may manifest later in life.
  • These findings highlight potential differences in neonatal metabolic programming between LGA and AGA infants.
Abstract

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