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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

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Published on: September 25, 2012

Targeting glioblastoma stem cells: cell surface markers.

J He1, Y Liu, D M Lubman

  • 1Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, 48109-0656, USA.

Current Medicinal Chemistry
|September 12, 2012
PubMed
Summary

Identifying novel glioblastoma stem cell (GSC) markers, especially on the cell surface, is crucial for targeting these cancer stem cells and improving glioblastoma treatment outcomes.

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Last Updated: May 18, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

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Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
09:36

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Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells
10:28

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Glioblastoma multiforme (GBM) is an aggressive primary brain tumor with poor prognosis.
  • Glioblastoma stem cells (GSCs) are implicated in tumor initiation, growth, and recurrence.
  • Effective GBM treatment requires targeting these critical GSCs.

Purpose of the Study:

  • To review recent advancements in identifying glioblastoma stem cell (GSC) markers.
  • To emphasize the importance of cell surface markers for GSC targeting.
  • To highlight the need for further characterization of GSC marker functions.

Main Methods:

  • Literature review of recent studies on GSC markers.
  • Focus on cell surface markers relevant to GSC identification and targeting.
  • Analysis of the functional roles of identified markers.

Main Results:

  • Several cell surface markers have been identified for GSC enrichment.
  • These markers show promise for therapeutic targeting of GSCs.
  • The functional significance of many GSC markers in GBM development is still under investigation.

Conclusions:

  • Cell surface markers are valuable targets for glioblastoma stem cell therapies.
  • Further research is needed to elucidate the functional roles of GSC markers.
  • Novel GSC markers could significantly improve glioblastoma treatment strategies.