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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Updated: May 18, 2026

Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells
07:22

Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells

Published on: September 1, 2023

Stem cells in kidney regeneration.

Shinya Yokote1, Takashi Yokoo

  • 1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei, University School of Medicine, 3-25- 8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.

Current Medicinal Chemistry
|September 12, 2012
PubMed
Summary

Regenerative medicine uses stem cells to repair kidney disease and regenerate damaged kidney tissue. Research explores recruiting stem cells and factors for repair or rebuilding entire kidneys.

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Area of Science:

  • Regenerative medicine
  • Nephrology
  • Stem cell biology

Background:

  • Kidney diseases pose a significant health burden, necessitating novel therapeutic strategies.
  • Current treatments for kidney disease often focus on managing symptoms rather than addressing the underlying pathology.
  • Stem cell-based therapies offer a promising avenue for kidney repair and regeneration.

Purpose of the Study:

  • To review current advancements in stem cell research for kidney tissue repair.
  • To explore strategies for de novo kidney organ regeneration using stem cells.
  • To discuss the potential of various stem cell types in treating kidney diseases.

Main Methods:

  • Review of current literature on stem cell applications in kidney regeneration.
  • Analysis of strategies involving stem cell recruitment and dedifferentiation.
  • Examination of approaches for complete kidney organ regeneration.

Main Results:

  • Stem cells demonstrate potential in repairing injured kidney tissue and improving function.
  • Strategies include recruiting stem cells and soluble factors to damaged kidney sites.
  • Induction of dedifferentiation in resident renal cells is another key approach.
  • De novo regeneration is explored for cases with complete structural disruption.

Conclusions:

  • Stem cell research is advancing kidney tissue repair and regeneration.
  • Multiple stem cell types show promise for therapeutic applications in nephrology.
  • Further research is needed to translate these findings into clinical practice for kidney disease treatment.